Bioanalytical LC-MS/MS Scientist (ADME/DMPK Studies)

Position Title: Bioanalytical LC
• MS/MS Scientist
Reports To: Head of Therapeutics / DMPK Group Leader
Location: Ai. BST, Chiedza Farm, Boronia Farm, Beatrice Zimbabwe
Employment Type: Full
• time
Position Summary
The Bioanalytical LC
• MS/MS Scientist will be responsible for developing, validating, and applying LC
• MS/MS methods to support ADME/DMPK studies at the institute. The role focuses on the quantitative analysis of drugs, metabolites, and biomarkers in biological samples to advance preclinical and translational research in drug discovery and development.

Key Responsibilities:
Key Responsibilities & Responsibilities
a) Develop and validate LC
• MS/MS bioanalytical methods for small molecules and metabolites.
b) Conduct bioanalysis of in vitro and in vivo ADME/DMPK studies (microsomal stability, permeability, PK profiling).
c) Analyze, interpret, and report LC
• MS/MS data in line with GLP/GCLP and regulatory guidelines.
d) Operate, maintain, and troubleshoot LC
• MS/MS instrumentation.
e) Ensure quality control and compliance with international standards (FDA, EMA, ICH).
f) Collaborate with medicinal chemists, pharmacologists, and toxicologists to guide drug discovery decisions.
g) Train and mentor apprentices, graduate students, and junior scientists.

Requirements and Experience
a) MSc or Ph. D in Analytical Chemistry, Pharmaceutical Sciences, Biochemistry, or related field.
b) Minimum 2 years of hands
• on LC
• MS/MS Experience in bioanalysis.
c) Strong Experience in ADME/DMPK studies and pharmacokinetic analysis.
d) Proficiency with LC
• MS/MS software (e.g., Analyst, Mass. Hunter, Skyline) and pharmacokinetic tools (Win. Nonlin/Phoenix).
e) Knowledge of international bioanalytical regulatory guidelines.
Core Skills
a) Strong analytical and problem
• solving Skills.
b) Attention to detail and commitment to quality.
c) Effective communication and teamwork Skills.
d) Ability to work independently in a fast
• paced research environment.
e) Mentorship and capacity building.

Key Responsibilities & Responsibilities
a) Develop and validate LC
• MS/MS bioanalytical methods for small molecules and metabolites.
b) Conduct bioanalysis of in vitro and in vivo ADME/DMPK studies (microsomal stability, permeability, PK profiling).
c) Analyze, interpret, and report LC
• MS/MS data in line with GLP/GCLP and regulatory guidelines.
d) Operate, maintain, and troubleshoot LC
• MS/MS instrumentation.
e) Ensure quality control and compliance with international standards (FDA, EMA, ICH).
f) Collaborate with medicinal chemists, pharmacologists, and toxicologists to guide drug discovery decisions.
g) Train and mentor apprentices, graduate students, and junior scientists.

How to applyTo apply for this position please submit in confidence a resume and a cover letter that details why you are a good fit for this position to gmudzingwa@aibst.edu.zw and copy smukanganyama@aibst.edu.zw with the subject: Bioanalytical LC MS/MS ScientistThe due date for submission of applications is 24 October 2025 at 17:00 CAT. All applications received after the deadline will not be considered.African Institute of Biomedical Science and Technology is an Equal Opportunity Employer!